Pharmacogenomic Biomarkers in Drug Labels2013-3-28版本AbacavirAdo-TrastuzumabEmtansine， 2013-3月添加AripiprazoleArsenic TrioxideAtomoxetineAtorvastatinAripiprazole4Arsenic Trioxide5Atomoxetine6Atorvastatin72013-2，Drug ListAbacavir32012-3,药品目录Abacavir3HER-2靶向抗体-药物共轭物Aripiprazole4Arsenic Trioxide5Atomoxetine6Atorvastatin7Azathioprine8Boceprevir9Brentuximab Vedotin10Busulfan11Capecitabine12Carbamazepine13Carisoprodol14Carvedilol15Celecoxib16Cetuximab (1)17Cetuximab (2)18Cevimeline19Chlordiazepoxide andAmitriptyline20Chloroquine21Cisplatin22Citalopram (1)23Citalopram (2)24Clobazam25Clomipramine27AzathioprineBoceprevirBrentuximab VedotinBusulfanCapecitabineCarbamazepineCarisoprodolCarvedilolCelecoxibCetuximab (1)Cetuximab (2)CevimelineChlordiazepoxide andAmitriptylineChloroquineCisplatinCitalopram (1)Citalopram (2)ClobazamClomipramineAzathioprine8Boceprevir9Brentuximab Vedotin10Busulfan11Capecitabine12Carbamazepine13Carisoprodol14Carvedilol15Celecoxib16Cetuximab (1)17Cetuximab (2)18Cevimeline19Chlordiazepoxide andAmitriptyline20Chloroquine21Cisplatin22Citalopram (1)23Citalopram (2)24Clobazam25Clomipramine27ClopidogrelClozapineCodeineCrizotinibDapsoneClopidogrel28Clozapine29Codeine30Crizotinib31Dapsone32Clopidogrel28Clozapine29Codeine30Crizotinib31Dapsone32DasatinibDasatinib33Dasatinib33Denileukin DiftitoxDesipramineDexlansoprazole (1)Dexlansoprazole (2)Dextromethorphan andQuinidineDiazepamDoxepinDrospirenone and EthinylEstradiolEltrombopag (1)Eltrombopag (2)Denileukin Diftitox34Desipramine35Dexlansoprazole (1)36Dexlansoprazole (2)37Dextromethorphan andQuinidine38Diazepam39Doxepin40Drospirenone and EthinylEstradiol41Eltrombopag (1)42Eltrombopag (2)432013-2月添加DesipramineDexlansoprazole (1)36Dexlansoprazole (2)37Dextromethorphan andQuinidine38Diazepam39Doxepin40Drospirenone and EthinylEstradiol41ErlotinibEsomeprazoleEverolimusErlotinib44Esomeprazole45Everolimus46Erlotinib42Esomeprazole43ExemestaneFluorouracilExemestane47Exemestane44Fluorouracil45Fluoxetine andOlanzapine47Fluoxetine46Flurbiprofen48Fluvoxamine (1)49Fulvestrant52Fluorouracil48Fluoxetine andFluoxetineOlanzapine50Fluoxetine and OlanzapineFluoxetine49FlurbiprofenFlurbiprofen51FluvoxamineFluvoxamine 52FulvestrantFulvestrant53GalantamineGefitinibGalantamine54Gefitinib 55Galantamine53Gefitinib (1)54IloperidoneImatinib (1)Imatinib (2)Imatinib (3)Imatinib (4)ImipramineIndacaterolIrinotecanIsosorbide and HydralazineIvacaftorLansoprazole， 2013-3月添加Iloperidone56Imatinib (1)57Imatinib (2)58Imatinib (3)59Imatinib (4)60Imipramine61Indacaterol62Irinotecan63Isosorbide andHydralazine64Ivacaftor65Iloperidone56Imatinib (1)57Imatinib (2)58Imatinib (3)59Imatinib (4)60Imipramine61Indacaterol62Irinotecan63Isosorbide andHydralazine64Ivacaftor65LapatinibLapatinib66Lapatinib66LenalidomideLenalidomide67Lenalidomide67LetrozoleMaravirocMercaptopurineMetoprololModafinilMycophenolic AcidNefazodoneNilotinib (1)Letrozole68Maraviroc69Mercaptopurine70Metoprolol71Modafinil 72Mycophenolic Acid73Nefazodone74Nilotinib (1)75Letrozole68Maraviroc69Mercaptopurine70Metoprolol71Modafinil (1)722013年2月添加Nefazodone74Nilotinib (1)76Nilotinib (2)NortriptylineOmeprazoleNilotinib (2)76Nortriptyline77Omeprazole78Nilotinib (2)77Nortriptyline78Omeprazole79Panitumumab (1)Panitumumab (1)79Panitumumab (1)80Panitumumab (2)PantoprazoleParoxetinePeginterferon alfa-2bPerphenazinePertuzumabPhenytoinPimozidePrasugrelPravastatinPropafenonePropranololProtriptylineQuinidineRabeprazoleRasburicaseRifampin, Isoniazid, andPyrazinamideRisperidonePanitumumab (2)80Pantoprazole81Paroxetine82Peginterferon alfa-2b83Perphenazine84Pertuzumab85Phenytoin86Pimozide87Prasugrel88Pravastatin89Propafenone90Propranolol91Protriptyline92Quinidine93Rabeprazole94Rasburicase95Rifampin, Isoniazid, andPyrazinamide96Risperidone97Panitumumab (2)81Pantoprazole82Paroxetine83Peginterferon alfa-2b84Perphenazine85Phenytoin86Pimozide87Prasugrel88Pravastatin89Propafenone90Propranolol91Protriptyline92Quinidine93Rabeprazole94Rasburicase95Rifampin, Isoniazid, andPyrazinamide96Risperidone97Sodium Phenylacetate andSodium Phenylacetate andSodium Phenylacetate andSodium BenzoateSodium Benzoate98Sodium Benzoate98Sodium PhenylbutyrateTamoxifen (1)Tamoxifen (2)Tamoxifen (3)TelaprevirTerbinafineSodium Phenylbutyrate99Sodium Phenylbutyrate99Tamoxifen (1)100Tamoxifen (2)101Tamoxifen (3)102Telaprevir103Terbinafine104Telaprevir101Terbinafine102Tamoxifen100TetrabenazineThioguanineThioridazineTicagrelorTolterodineTetrabenazine105Thioguanine106Thioridazine107Ticagrelor108Tolterodine109Thioguanine104Thioridazine105Ticagrelor106Tolterodine109TositumomabTramadol andAcetaminophenTrastuzumabTretinoinTrimipramineValproic AcidTositumomab110Tramadol andAcetaminophen111Trastuzumab112Tretinoin113Trimipramine114Valproic Acid115Tositumomab110Tramadol andAcetaminophen111Trastuzumab112Tretinoin113Trimipramine114Valproic Acid115VemurafenibVenlafaxineVoriconazoleWarfarin (1)Warfarin (2)Vemurafenib116Venlafaxine117Voriconazole118Warfarin (1)119Warfarin (2)120Vemurafenib116Venlafaxine117Voriconazole118Warfarin (1)119Warfarin (2)120ug Labels公司阿巴卡韦T-DM1阿立哌唑三氧化二砷托莫西汀阿伐他汀礼来辉瑞罗氏Therapeutic Area抗病毒 艾滋病Antivirals肿瘤HER2阳性晚期(转移性)乳腺Oncology癌Psychiatry精神-神经 精神分裂症肿瘤Oncology急性早幼粒细胞白血病精神-神经，儿童多动症心血管 高脂血症骨骼-肌肉，风湿肿瘤抗病毒-丙肝肿瘤霍杰金淋巴瘤(HL)；系统性间变性大细胞淋巴瘤肿瘤慢性粒细胞性白血病肿瘤精神-神经，癫痫骨骼-肌肉，肌松心血管 高血压PsychiatryMetabolic andEndocrinologyRheumatologyAntiviralsOncologyOncologyOncologyNeurologyMusculoskeletalCardiovascularAnalgesicsOncologyOncologyDermatology and DentalPsychiatryAntiinfectivesOncologyPsychiatry硫唑嘌呤抗丙型肝炎抗体—药物偶联物马里兰卡培他滨卡马西平卡立普多；肌安宁卡维地络塞来昔布西妥昔单抗西妥昔单抗西维美林氯氮卓 和阿米替林氯喹顺铂西酞普兰西酞普兰氯巴占；氧异安定氯米帕明罗氏诺华辉瑞德国默克德国默克骨骼肌肉-NSAID肿瘤（爱必妥，德国默克）结直肠癌，头颈癌肿瘤（爱必妥，德国默克）结直肠癌，头颈癌干燥综合征精神-神经，抑郁抗感染，疟疾肿瘤精神-神经，抑郁Psychiatry精神-神经，抑郁精神-神经，丹麦灵北制药，严重类型Lennox-Gastaut综Neurology合征的癫痫Psychiatry精神-神经 抑郁，三环类氯吡格雷氯氮平可待因克卓替尼氨苯砜赛诺菲心血管-抗凝精神-神经，精神分裂症骨骼肌肉-镇痛CardiovascularPsychiatryAnalgesicsOncologyDermatology and Dental辉瑞肿瘤-肺癌（ALK阳性的非小细胞肺癌）抗感染，麻风病肿瘤BMS公司,对伊马替尼治疗耐药或不耐受,费城染色体阳性(Ph+)de 慢性髓细胞白血病肿瘤Ligand公司，治疗皮肤T淋巴瘤(CTCL)精神-神经，内源性,更年期、反应性及神经性抑郁症胃肠胃肠精神-神经Avanir 公司2011年上市，假性球麻痹症状适应症精神-神经精神-神经 精神分裂症泌尿生殖血液 血小板减少症血液 血小板减少症肿瘤罗氏，特罗凯，EGFR突变的非小细胞肺癌，胰腺癌胃肠肿瘤（西罗莫司的衍生物），胰腺癌和肾细胞癌；激素阳性、Her2标志物阴性的晚期乳肿瘤（他莫苷芬治疗后病情进展的绝经后晚期乳腺癌）肿瘤精神-神经，抑郁精神-神经，抑郁骨骼-肌肉，风湿精神-神经，抑郁肿瘤乳腺癌，雌激素受体拮抗剂，AZ达沙替尼BMSOncology白介素II-融合毒素地昔帕明右旋兰索拉唑右旋兰索拉唑右美沙芬和奎尼丁安定多塞平屈螺酮 + 炔雌醇艾曲波帕艾曲波帕Ligand公司OncologyPsychiatryGastroenterologyGastroenterologyNeurologyPsychiatryPsychiatryReproductiveHematologyHematology埃罗替尼左旋奥美拉唑依维莫司罗氏OncologyGastroenterologyOncology依西美坦五氟脲嘧啶，5-FU氟西汀 + 奥氮平氟西汀氟比洛芬氟伏沙明氟维司群罗氏OncologyOncologyPsychiatryPsychiatryRheumatologyPsychiatryOncology加兰他敏吉非替尼阿斯利康精神-神经，轻度到中度阿尔Neurology茨海默型痴呆症状肿瘤OncologyAZ，易瑞沙，肺癌（NSCLC）精神-神经，精神分裂症PsychiatryOncologyOncologyOncologyOncologyPsychiatryPulmonaryOncologyCardiovascular伊潘立酮伊马替尼伊马替尼伊马替尼伊马替尼丙咪嗪茚达特罗粉雾剂(吸入)伊立替康异山梨醇 和氢氯噻嗪Vertex公司，兰索拉唑武田诺华辉瑞诺华诺华诺华诺华肿瘤肿瘤肿瘤肿瘤精神-神经，抑郁呼吸-COPD肿瘤心血管-B，黑人慢性心衰呼吸-治疗罕见型囊性纤维化PulmonaryGastroenterology肿瘤联合卡培他滨治疗Her-2过度表达的,既往接受过包括蒽环Oncology类,紫杉醇,曲妥珠单抗(赫赛汀)治疗的晚期或转移性乳腺癌肿瘤多发性骨髓瘤；具有5q缺失细胞遗传学异常的骨髓增生Oncology异常综合征所致的输血依赖性贫血患者肿瘤Oncology乳腺癌,激素治疗抗病毒 艾滋病（CCR5拮抗剂，辉瑞）Antivirals拉帕替尼来那度胺来曲唑马拉维诺巯基嘌呤美托洛尔莫达非尼骁悉，吗替麦考酚酯奈法唑酮尼罗替尼诺华辉瑞阿斯利康罗氏骨骼-肌肉，风湿Oncology肿瘤Cardiovascular心血管 高血压Psychiatry精神-神经，中枢兴奋剂免疫抑制，2012-12月添加的TransplantationPsychiatry精神-神经，抑郁（2004年因不良反应撤市）肿瘤对既往治疗（包括伊马替Oncology尼）耐药或不耐受的费城染色体阳性的慢性髓性白血病尼罗替尼去甲替林奥美拉唑肿瘤对既往治疗（包括伊马替尼）耐药或不耐受的费城染色体阳性的慢性髓性白血病精神-神经，抑郁胃肠OncologyPsychiatryGastroenterology帕尼单抗肿瘤结直肠癌治疗药Vectibix(panitumumab、帕Oncology尼单抗)是第一个完全人源化单克隆抗体，其靶向作用于表皮生长因子受体(EGFR)肿瘤胃肠GSK罗氏精神-神经 抑郁抗病毒，丙肝精神-神经 精神分裂症肿瘤Her2阳性的乳腺癌OncologyGastroenterologyPsychiatryAntiviralsPsychiatryOncology帕尼单抗泮托拉唑帕罗西汀长效a-2b干扰素奋乃静帕妥珠单抗苯妥英钠匹莫齐特普拉格雷，抗凝普伐他汀普罗帕酮普萘洛尔普罗替林奎尼丁雷贝拉唑拉布立酶雷米封,异烟肼,吡嗪酰胺利培酮乙酸钠和苯甲酸钠礼来罗氏Neurology精神-神经 癫痫精神-神经，急、慢性精神分Psychiatry裂症心血管 抗凝心血管 高脂血症心血管 心律失常心血管 高血压精神-神经心血管 心律失常胃肠肿瘤化疗后的高尿酸血症抗感染 结核精神-神经 精神分裂症胃肠（UCD相关的高氨血症）急性高氨血症及尿素循环酶缺乏患者的相关脑病胃肠 高氨血症肿瘤 乳腺癌肿瘤 乳腺癌肿瘤 乳腺癌抗病毒 艾滋病抗感染 真菌CardiovascularCardiovascular andEndocrinologyCardiovascularCardiovascularPsychiatryAntiarrhythmicsGastroenterologyOncologyAntiinfectivesPsychiatryGastroenterology苯丁酸钠他莫昔芬他莫昔芬他莫昔芬特拉匹韦盐酸特比萘芬片GastroenterologyOncologyOncologyOncologyAntiviralsAntifungals丁苯那嗪硫代鸟嘌呤硫代鸟嘌呤替卡格雷托特罗定阿斯利康Neurology精神-神经，亨廷顿病相关舞蹈症骨骼-肌肉，风湿肿瘤骨骼-肌肉，风湿肿瘤心血管 抗凝泌尿生殖 尿失禁OncologyPsychiatryCardiovascularReproductive andUrologic托西莫单抗GSK曲马多 和 对乙氨基酚曲妥珠单抗维甲酸曲米帕明（三甲丙咪嗪）丙戊酸罗氏肿瘤表达CD20抗原的复发性或难Oncology治性低分度滤泡状或已变形的NHL患者骨骼-肌肉，风湿Analgesics镇痛肿瘤 乳腺癌Oncology肿瘤 急性早幼粒细胞白血病Oncology精神-神经 抑郁精神-神经 癫痫肿瘤Braf阳性的晚期黑色素瘤精神-神经 抑郁抗感染 抗真菌心血管 抗凝心血管 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