Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :WYE-1251321144068-46-1HY-10044519.60C27H33N7O4>98%Solubility:DMSO ≥102mg/mL Water<1.2mg/mL Ethanol <1.2mg/mLMechanisms: Pathways:PI3K/Akt/mTOR ; Target:mTOR Pathways:PI3K/Akt/mTOR ; Target:PI3K gyBiological Activity:WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of0.19 nM.References:[1]. Zask, Arie et al Preparation of thienopyrimidine and pyrazolopyrimidine compounds and theiruse as mTOR kinase and PI3 kinase inhibitors. U.S. Pat. Appl. Publ. (2009), US 2009098086A1 [][2]. Ker Yu et al Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity ofypgpygyyWYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2 Cancer ResJanuary 15, 2010 70; 621 [3]. Yu K, Shi C, Toral-Barza L, Lucas J, Shor B, Kim JE, Zhang WG, Mahoney R, Gaydos C, TardioL, Kim SK, Conant R, Curran K, Kaplan J, Verheijen J, Ayral-Kaloustian S, Mansour TS, AbrahamRT, Zask A, Gibbons JJ.Beyond rapalog therapy: preclinical pharmacology and antitumor activity ofWYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.Cancer Res.2010 Jan 15;70(2):621-31. Epub 2010 Jan 12. [4]. Yu K, Toral-Barza L.Biochemical an...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
