脑卒中康复过程中γ-氨基丁酸对神经可塑性的调节作用

脑卒中康复过程中γ-氨基丁酸对神经可塑性的调节作用

脑卒中是导致长期残疾的首要原因。依据其病变位置的和大小大多数脑卒中病人在最初3-6个月可部分或完全恢复功能。在功能恢复阶段，皮质重组，可塑性发生，生理反应或神经元兴奋性会在损伤对侧部位发生变化。然而，GABA相关研究的开展，如何提高脑卒中后神经可塑性、促进脑卒中功能恢复未得到充分阐释。

γ-氨基丁酸（GABA）是大脑中主要的抑制性神经递质，对大鼠大脑运动皮层的可塑性发挥调节作用。但其在成年人体大脑病变的抑制作用并没有充分研究。韩国首尔国立大学的Nam-Jong Paik教授认为检测GABA活性可以作为脑卒中后康复的潜在生物标志物。GABA相关研究的开展或许利于脑卒中后更有效的康复干预措施开发。相关研究内容发表在2014年12月第23期《中国神经再生研究（英文版）》杂志上。

Article: \"Role of GABA plasticity in stroke recovery \" by Nam-Jong Paik, EunJoo Yang (Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea)

Paik NJ, Yang E. Role of GABA plasticity in stroke recovery. Neural Regen Res. 2014;9(23):2026-2028.

SICENCE新闻发布 作者：Nam-Jong Paik 稿号：NRR-D-14-00290

Role of GABA plasticity in stroke recovery

Stroke is a leading cause of long-term disability. Most stroke patients regain their function partially or fully during the first 3-6 months depending on location and size of the lesion. During this functional recovery phase, cortical reorganization or plasticity occurs, and physiological responsiveness or neuronal excitability is altered in the ipsilesional and contralesional areas. However, how to drive successful plastic changes or successful stroke recovery are not fully elucidated yet. γ-Aminobutyric acid (GABA) is the dominant inhibitory neurotransmitter in the brain and GABA plasticity are known to play an important role in stroke recovery. The role of GABAergic modulation in motor cortical plasticity is well established in rat brains, however, the role of peri-lesional inhibition in human adult brain is less well understood, yet. Prof. Nam-Jong Paik, who comes from Seoul National University, South Korea considered that measuring GABA activity could serve as a potential biomarker for post-stroke recovery. Future studies with a larger sample size correlating GABAergic activation patterns with functional recovery are needed to identify the neuroanatomical substrates that subserve functional recovery. Such researches might also guide the development of more effective rehabilitative interventions for functinal improvement after a stroke. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 23, 2014).

Article: \"Role of GABA plasticity in stroke recovery \" by Nam-Jong Paik, EunJoo Yang (Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea)

Paik NJ, Yang E. Role of GABA plasticity in stroke recovery. Neural Regen Res. 2014;9(23):2026-2028.

更多信息 Neural Regeneration Research